The Best Guess Approach to Phase I Trial Design

The Best Guess Hypothesis in Multistage Inference i

Intuitive multistage inferences are typically excessive when compared with the optimal model, a modified form of Bayes' theorem. One explanation for this excessiveness is that the S primarily attends to the implications of the probable event described by the first-stage inference, neglecting the implications of less likely events. If a S follows this strategy, called a "best guess" strategy, th...

Phase I Clinical Trial Design

Phase 1 trial design: is 3 + 3 the best?

BACKGROUND Concerns have been recognized about the operating characteristics of the standard 3 + 3 dose-escalation design. Various innovative phase 1 trial designs have been proposed to address the issues and new challenges posed by molecularly targeted agents. However, in spite of these proposals, the conventional design is still the most widely utilized. METHODS A review of the literature o...

from linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar

chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...

non-corrective approach to pronunciation

the aim of this study has been to find answers for the following questions: 1. what is the effect of immediate correction on students pronunciation errors? 2. what would be the effect of teaching the more rgular patterns of english pronunciation? 3. is there any significant difference between the two methods of dealing with pronuciation errore, i. e., correction and the teaching of the regular ...